Skin cancer in people with multiple sclerosis: a record linkage study

被引:60
作者
Goldacre, MJ
Seagroatt, V
Yeates, D
Acheson, ED
机构
[1] Univ Oxford, Inst Hlth Sci, Dept Publ Hlth, Unit Hlth Care Epidemiol, Oxford OX3 7LF, England
[2] UCL, Sch Med, Dept Epidemiol, London W1N 8AA, England
关键词
D O I
10.1136/jech.58.2.142
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objective: The prevalence of multiple sclerosis (MS) varies with latitude: it increases with distance from the equator in both hemispheres. To seek evidence on whether solar radiation is a protective factor for MS, this study investigated whether skin cancer, as an indicator of solar radiation, is less common in people with MS than in others. Design: Analysis of a database of linked hospital records and death certificates. Setting: The Oxford Region of the National Health Service, England. Subjects: A cohort comprising all people in the database with MS, and comparison cohorts of people with other diseases. Results: Skin cancer was significantly less common in people with MS than in the main comparison cohort (rate ratio 0.49; 95% confidence interval 0.24 to 0.91). There was no general deficit of cancer in the MS cohort, and no deficit of skin cancer in cohorts of people with other autoimmune or neurological diseases. Conclusion: The findings support the hypothesis that solar radiation may have a protective influence on the development of MS.
引用
收藏
页码:142 / 144
页数:3
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