Molecularly imprinted polymers selective for β-estradiol

被引：15

作者：

Rachkov, A

McNiven, S

Cheong, SH

El'Skaya, A

Yano, K

Karube, I

机构：

[1] Univ Tokyo, Adv Sci & Technol Res Ctr, Meguro Ku, Tokyo 153, Japan

[2] Natl Acad Sci Ukraine, Inst Mol Biol & Genet, UA-252143 Kiev, Ukraine

来源：

SUPRAMOLECULAR CHEMISTRY | 1998年 / 9卷 / 04期

关键词：

molecular recognition; molecularly imprinted polymer; beta-estradiol; solvent properties;

D O I：

10.1080/10610279808035001

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polymers able to recognize the female steroid hormone, beta -estradiol, have been synthesized using molecular imprinting based on non-covalent interactions. A chromatographic study of the polymers demonstrated a strong dependence of the selectivity and strength of their interaction with analytes on the solvents used both as porogen and chromatographic mobile phase. Hydrogen bonding between the OH-group at C-17 of beta -estradiol and methacrylic acid (the functional monomer of the polymer) plays a major role in the process of molecular recognition but hydrophobic and dipole-dipole interactions also contribute.

引用

页码：317 / 323

页数：7

共 17 条

[1] MIMICS OF THE BINDING-SITES OF OPIOID RECEPTORS OBTAINED BY MOLECULAR IMPRINTING OF ENKEPHALIN AND MORPHINE [J].