Increased CD56(+) natural killer cells and related cytokines in major depression

被引：101

作者：

Seidel, A ^{[1
]}

Arolt, V ^{[1
]}

Hunstiger, M ^{[1
]}

Rink, L ^{[1
]}

Behnisch, A ^{[1
]}

Kirchner, H ^{[1
]}

机构：

[1] UNIV LUBECK,SCH MED,DEPT PSYCHIAT,D-23538 LUBECK,GERMANY

来源：

CLINICAL IMMUNOLOGY AND IMMUNOPATHOLOGY | 1996年 / 78卷 / 01期

关键词：

D O I：

10.1006/clin.1996.0012

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Twenty-seven inpatients with major depression were examined four times within 6 weeks to assess CD56(+) natural killer (NR) cell counts by flow cytometry and to assess the related lymphokines interleukin-2 and interferon-gamma in a whole blood assay after mitogen stimulation with phytohemagglutinin (PHA). The patients showed significantly higher counts of the fraction of 56(+) NK cells and a greater lymphokine response to PHA than the controls. A significant correlation between lymphokine secretion and CD56(+) cell counts was detected in the patients' acute clinical stage, but not in healthy controls or in patients after clinical improvement. (C) 1996 Academic Press Inc.

引用

页码：83 / 85

页数：3

共 16 条

[1] DEPRESSION AND IMMUNITY - AGE, SEVERITY, AND CLINICAL COURSE [J].

ANDREOLI, AV ;

KELLER, SE ;

RABAEUS, M ;

MARIN, P ;

BARTLETT, JA ;

TABAN, C .

BRAIN BEHAVIOR AND IMMUNITY, 1993, 7 (04) :279-292

[2] CELLULAR-IMMUNITY AND THE HYPOTHALAMIC-PITUITARY AXIS IN MAJOR AFFECTIVE-DISORDER - A PRELIMINARY-STUDY [J].

DARKO, DF ;

LUCAS, AH ;

GILLIN, JC ;

RISCH, SC ;

GOLSHAN, S ;

HAMBURGER, RN ;

SILVERMAN, MB ;

JANOWSKY, DS .

PSYCHIATRY RESEARCH, 1988, 25 (01) :1-9

[3] NEOPTERIN MEASUREMENT PROVIDES EVIDENCE OF ALTERED CELL-MEDIATED-IMMUNITY IN PATIENTS WITH DEPRESSION, BUT NOT WITH SCHIZOPHRENIA [J].

DUNBAR, PR ;

HILL, J ;

NEALE, TJ ;

MELLSOP, GW .

PSYCHOLOGICAL MEDICINE, 1992, 22 (04) :1051-1057

[4]

EVANS DL, 1992, ARCH GEN PSYCHIAT, V49, P388

[5] MAJOR DEPRESSION AND IMMUNITY - PRELIMINARY EVIDENCE OF DECREASED NATURAL-KILLER CELL-POPULATIONS [J].

EVANS, DL ;

PEDERSEN, CA ;

FOLDS, JD .

PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 1988, 12 (05) :739-748

[6] A RATING SCALE FOR DEPRESSION [J].

HAMILTON, M .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1960, 23 (01) :56-62

[7] A WHOLE-BLOOD TECHNIQUE FOR TESTING PRODUCTION OF HUMAN INTERFERON BY LEUKOCYTES [J].

KIRCHNER, H ;

KLEINICKE, C ;

DIGEL, W .

JOURNAL OF IMMUNOLOGICAL METHODS, 1982, 48 (02) :213-219

[8] ABSOLUTE NUMBER AND PERCENTAGE OF CIRCULATING NATURAL-KILLER, NON-MHC-RESTRICTED T-CYTOTOXIC, AND PHAGOCYTIC-CELLS IN UNIPOLAR DEPRESSION [J].

MAES, M ;

LAMBRECHTS, J ;

SUY, E ;

VANDERVORST, C ;

BOSMANS, E .

NEUROPSYCHOBIOLOGY, 1994, 29 (04) :157-163

[9] INCREASED NEOPTERIN AND INTERFERON-GAMMA SECRETION AND LOWER AVAILABILITY OF L-TRYPTOPHAN IN MAJOR DEPRESSION - FURTHER EVIDENCE FOR AN IMMUNE-RESPONSE [J].

MAES, M ;

SCHARPE, S ;

MELTZER, HY ;

OKAYLI, G ;

BOSMANS, E ;

DHONDT, P ;

VANDEN BOSSCHE, B ;

COSYNS, P .

PSYCHIATRY RESEARCH, 1994, 54 (02) :143-160

[10] EVIDENCE FOR A SYSTEMIC IMMUNE ACTIVATION DURING DEPRESSION - RESULTS OF LEUKOCYTE ENUMERATION BY FLOW-CYTOMETRY IN CONJUNCTION WITH MONOCLONAL-ANTIBODY STAINING [J].

MAES, M ;

LAMBRECHTS, J ;

BOSMANS, E ;

JACOBS, J ;

SUY, E ;

VANDERVORST, C ;

DEJONCKHEERE, C ;

MINNER, B ;

RAUS, J .

PSYCHOLOGICAL MEDICINE, 1992, 22 (01) :45-53

← 1 2 →