Carbohydrate and the cytokine response to 2.5 h of running

被引:257
作者
NehlsenCannarella, SL
Fagoaga, OR
Nieman, DC
Henson, DA
Butterworth, DE
Schmitt, RL
Bailey, EM
Warren, BJ
Utter, A
Davis, JM
机构
[1] APPALACHIAN STATE UNIV,DEPT HLTH LEISURE & EXERCISE SCI,BOONE,NC 28608
[2] APPALACHIAN STATE UNIV,DEPT BIOL,BOONE,NC 28608
[3] LOMA LINDA UNIV,MED CTR,CTR IMMUNOL,LOMA LINDA,CA 92350
[4] LOMA LINDA UNIV,MED CTR,DEPT PATHOL,LOMA LINDA,CA 92350
[5] UNIV S CAROLINA,SCH PUBL HLTH,DEPT EXERCISE SCI,COLUMBIA,SC 29208
关键词
immune system; cortisol; interleukin-6; interleukin-1; interleukin-1-receptor antagonist;
D O I
10.1152/jappl.1997.82.5.1662
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
This randomized, double-blind, placebo-controlled study was designed to determine the influence of 6% carbohydrate (C) vs. placebo (P) beverage ingestion on cytokine responses (5 total samples over 9 h) to 2.5 h of high-intensity running (76.7 +/- 0.4% maximal O-2 uptake) by 30 experienced marathon runners. For interleukin-g (IL-6), a difference in the pattern of change between groups was found, highlighted by a greater increase in P vs. C immediately postrun (753 vs. 421%) and 1.5 h postrun (193 vs. 86%) [F(4,112) = 3.77, P = 0.006]. For interleukin-l-receptor antagonist (IL-1ra), a difference in the pattern of change between groups was found, highlighted by a greater increase in P vs. C 1.5 h postrun (231 vs. 72%) [F(2,50) = 6.38, P = 0.003]. No significant interaction effects mere seen for bioactive IL-6 or IL-1 beta. The immediate postrun plasma glucose concentrations correlated negatively with those of plasma cortisol (r = -0.67, P < 0.001); postrun plasma cortisol (r = 0.70, P < 0.001) and IL-6 levels (r = 0.54, P = 0.003) correlated positively with levels of IL-1ra. Taken together, the data indicate that carbohydrate ingestion attenuates cytokine levels in the inflammatory cascade in response to heavy exertion.
引用
收藏
页码:1662 / 1667
页数:6
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