Sir2: An NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging

被引：115

作者：

Imai, S ^{[1
]}

Johnson, FB ^{[1
]}

Marciniak, RA ^{[1
]}

McVey, M ^{[1
]}

Park, PU ^{[1
]}

Guarente, L ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY | 2000年 / 65卷

关键词：

D O I：

10.1101/sqb.2000.65.297

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：297 / 302

页数：6

共 44 条

[1]

ADAMIETZ P, 1984, J BIOL CHEM, V259, P6841

[2] Characterization of a human gene with sequence homology to Saccharomyces cerevisiae SIR2 [J].

Afshar, G ;

Murnane, JP .

GENE, 1999, 234 (01) :161-168

[3] THE SIR2 GENE FAMILY, CONSERVED FROM BACTERIA TO HUMANS, FUNCTIONS IN SILENCING, CELL-CYCLE PROGRESSION, AND CHROMOSOME STABILITY [J].

BRACHMANN, CB ;

SHERMAN, JM ;

DEVINE, SE ;

CAMERON, EE ;

PILLUS, L ;

BOEKE, JD .

GENES & DEVELOPMENT, 1995, 9 (23) :2888-2902

[4]

Braunstein M, 1996, MOL CELL BIOL, V16, P4349

[5] Transcriptional silencing of Ty1 elements in the RDN1 locus of yeast [J].

Bryk, M ;

Banerjee, M ;

Murphy, M ;

Knudsen, KE ;

Garfinkel, DJ ;

Curcio, MJ .

GENES & DEVELOPMENT, 1997, 11 (02) :255-269

[6] Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity [J].

Frye, RA .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 260 (01) :273-279

[7]

Gompertz B., 1825, PHILOS T ROY SOC LON, V115, P513, DOI DOI 10.1098/RSTL.1825.0026

[8] A NEW ROLE FOR A YEAST TRANSCRIPTIONAL SILENCER GENE, SIR2, IN REGULATION OF RECOMBINATION IN RIBOSOMAL DNA [J].

GOTTLIEB, S ;

ESPOSITO, RE .

CELL, 1989, 56 (05) :771-776

[9] POSITION EFFECT AT SACCHAROMYCES-CEREVISIAE TELOMERES - REVERSIBLE REPRESSION OF POL-II TRANSCRIPTION [J].

GOTTSCHLING, DE ;

APARICIO, OM ;

BILLINGTON, BL ;

ZAKIAN, VA .

CELL, 1990, 63 (04) :751-762

[10] HISTONE H3 AND H4 N-TERMINI INTERACT WITH SIR3 AND SIR4 PROTEINS - A MOLECULAR-MODEL FOR THE FORMATION OF HETEROCHROMATIN IN YEAST [J].

HECHT, A ;

LAROCHE, T ;

STRAHLBOLSINGER, S ;

GASSER, SM ;

GRUNSTEIN, M .

CELL, 1995, 80 (04) :583-592

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