Sir2: An NAD-dependent histone deacetylase that connects chromatin silencing, metabolism, and aging

被引：115

作者：

Imai, S ^{[1
]}

Johnson, FB ^{[1
]}

Marciniak, RA ^{[1
]}

McVey, M ^{[1
]}

Park, PU ^{[1
]}

Guarente, L ^{[1
]}

机构：

[1] MIT, Dept Biol, Cambridge, MA 02139 USA

来源：

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY | 2000年 / 65卷

关键词：

D O I：

10.1101/sqb.2000.65.297

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：297 / 302

页数：6

共 44 条

[31] Extrachromosomal rDNA circles - A cause of aging in yeast [J].

Sinclair, DA ;

Guarente, L .

CELL, 1997, 91 (07) :1033-1042

[32] Loss of transcriptional silencing causes sterility in old mother cells of S-cerevisiae [J].

Smeal, T ;

Claus, J ;

Kennedy, B ;

Cole, F ;

Guarente, L .

CELL, 1996, 84 (04) :633-642

[33] A phylogenetically conserved NAD+-dependent protein deacetylase activity in the Sir2 protein family [J].

Smith, JS ;

Brachmann, CB ;

Celic, I ;

Kenna, MA ;

Muhammad, S ;

Starai, VJ ;

Avalos, JL ;

Escalante-Semerena, JC ;

Grubmeyer, C ;

Wolberger, C ;

Boeke, JD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (12) :6658-6663

[34]

SMITH RM, 1997, CURR ORTHOPAED, V11, P24

[35] Oxidative stress, caloric restriction, and aging [J].

Sohal, RS ;

Weindruch, R .

SCIENCE, 1996, 273 (5271) :59-63

[36] Net1, a Sir2-associated nucleolar protein required for rDNA silencing and nucleolar integrity [J].

Straight, AF ;

Shou, WY ;

Dowd, GJ ;

Turck, CW ;

Deshaies, RJ ;

Johnson, AD ;

Moazed, D .

CELL, 1999, 97 (02) :245-256

[37]

STREHLER B, 1982, TIME CELLS AGING

[38] An enzymatic activity in the yeast Sir2 protein that is essential for gene silencing [J].

Tanny, JC ;

Dowd, GJ ;

Huang, J ;

Hilz, H ;

Moazed, D .

CELL, 1999, 99 (07) :735-745

[39] HISTONE H3 AMINO-TERMINUS IS REQUIRED FOR TELOMERIC AND SILENT MATING LOCUS REPRESSION IN YEAST [J].

THOMPSON, JS ;

LING, XF ;

GRUNSTEIN, M .

NATURE, 1994, 369 (6477) :245-247

[40] Purification and characterization of CobT, the nicotinate-mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase enzyme from Salmonella typhimurium LT2 [J].

Trzebiatowski, JR ;

EscalanteSemerena, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (28) :17662-17667

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