A new leishmanicidal saponin from Brunfelsia grandiflora

被引：21

作者：

Fuchino, Hiroyuki ^{[1
]}

Sekita, Setsuko ^{[2
]}

Mori, Kanami ^{[2
]}

Kawahara, Nobuo ^{[3
]}

Satake, Motoyoshi ^{[4
]}

Kiuchi, Fumiyuki ^{[1
]}

机构：

[1] Natl Inst Biomed Innovat, Res Ctr Med Plant Resources, Tsukuba, Ibaraki 3050843, Japan

[2] Tokushima Bunri Univ, Kagawa 7692193, Japan

[3] Natl Inst Hlth Sci, Setagaya Ku, Tokyo 1588501, Japan

[4] Ochanomizu Univ, Inst Environm Sci Human Life, Tokyo 1128610, Japan

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 2008年 / 56卷 / 01期

关键词：

Leishmania; Brunfelsia grandiflora; solanaceae; chiricsanango; furostan;

D O I：

10.1248/cpb.56.93

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new furostan-type saponin (1) was isolated from the methanolic extract of Brunfelsia grandiflora leaves, together with four known compounds. The chemical structure of I was determined by spectroscopic analysis and chemical reaction to be 26-O-beta-D-glueopyranosyl 22 alpha-methoxyfurost-3 beta,26-diol 3-O-beta-D-xylopyranosyl(1 -> 3)-{beta-D-glucopyranosyl(1 -> 2)}-beta-D-glucopyranosyl(1 -> 4)-beta-D-glueopyranoside. Compound 1 showed potent leishmanicidal activity in vitro against Leishmania major.

引用

页码：93 / 96

页数：4

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