OARSI Clinical Trials Recommendations: Knee imaging in clinical trials in osteoarthritis

被引：132

作者：

Hunter, D. J. ^{[1
,2
]}

Altman, R. D. ^{[3
]}

Cicuttini, Flavia M. ^{[4
]}

Crema, M. D. ^{[5
,6
]}

Duryea, J. ^{[7
]}

Eckstein, F. ^{[8
,9
]}

Guermazi, A. ^{[5
]}

Kijowski, R. ^{[10
]}

Link, T. M. ^{[11
]}

Martel-Pelletier, J. ^{[12
]}

Miller, C. G. ^{[13
]}

Mosher, T. J. ^{[14
,15
]}

Ochoa-Albiztegui, R. E. ^{[16
]}

Pelletier, J. -P. ^{[12
]}

Peterfy, C. ^{[17
]}

Raynauld, J. -P. ^{[12
]}

Roemer, F. W. ^{[5
,18
]}

Totterman, S. M. ^{[19
]}

Gold, G. E. ^{[20
,21
,22
]}

机构：

[1] Univ Sydney, Kolling Inst, Inst Bone & Joint Res, Sydney, NSW 2006, Australia

[2] Univ Sydney, Dept Rheumatol, Royal N Shore Hosp, Sydney, NSW 2006, Australia

[3] Univ Calif Los Angeles, David Geffen Sch Med, Div Rheumatol & Immunol, Dept Med, Los Angeles, CA 90095 USA

[4] Monash Univ, Alfred Hosp, Sch Publ Hlth & Prevent Med, Melbourne, Vic 3004, Australia

[5] Boston Univ, Sch Med, Quantitat Imaging Ctr, Dept Radiol, Boston, MA 02118 USA

[6] Hosp Coracao HCor & Teleimagem, Dept Radiol, Sao Paulo, SP, Brazil

[7] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Radiol, Sao Paulo, Brazil

[8] Paracelsus Med Univ Salzburg & Nuremberg, Inst Anat, Salzburg, Austria

[9] Chondrometrics GmbH, Ainring, Germany

[10] Univ Wisconsin, Dept Radiol, Sch Med & Publ Hlth, Madison, WI 53706 USA

[11] UCSF, Dept Radiol & Biomed Imaging, San Francisco, CA USA

[12] Univ Montreal Hosp Res Ctr CRCHUM, Osteoarthrit Res Unit, Montreal, PQ, Canada

[13] BioClinica, Newtown, PA USA

[14] Penn State Univ, Dept Radiol, Hershey, PA USA

[15] Penn State Univ, Dept Orthopaed Surg, Hershey, PA USA

[16] Amer British Cowdray Med Ctr, Dept Radiol, Mexico City, DF, Mexico

[17] Spire Sci Inc, Boca Raton, FL USA

[18] Univ Erlangen Nurnberg, Dept Radiol, D-91054 Erlangen, Germany

[19] Qmetr Technol, Rochester, NY USA

[20] Stanford Univ, Dept Radiol, Stanford, CA 94305 USA

[21] Stanford Univ, Dept Bioengn, Stanford, CA 94305 USA

[22] Stanford Univ, Dept Orthopaed Surg, Stanford, CA 94305 USA

来源：

OSTEOARTHRITIS AND CARTILAGE | 2015年 / 23卷 / 05期

基金：

澳大利亚国家健康与医学研究理事会;

关键词：

Knee osteoarthritis; Imaging; Clinical trial recommendations; JOINT-SPACE WIDTH; SPIRAL CT ARTHROGRAPHY; INDIVIDUAL RADIOGRAPHIC FEATURES; FIXED-FLEXION RADIOGRAPHY; HYALINE CARTILAGE DEFECTS; MEDIAL TIBIAL PLATEAU; ARTICULAR-CARTILAGE; BONE-MARROW; STANDING ANTEROPOSTERIOR; MODIFYING DRUG;

D O I：

10.1016/j.joca.2015.03.012

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

100224 [整形外科学];

摘要：

Significant advances have occurred in our understanding of the pathogenesis of knee osteoarthritis (OA) and some recent trials have demonstrated the potential for modification of the disease course. The purpose of this expert opinion, consensus driven exercise is to provide detail on how one might use and apply knee imaging in knee OA trials. It includes information on acquisition methods/techniques (including guidance on positioning for radiography, sequence/protocol recommendations/hardware for magnetic resonance imaging (MRI)); commonly encountered problems (including positioning, hardware and coil failures, sequences artifacts); quality assurance (QA)/control procedures; measurement methods; measurement performance (reliability, responsiveness, validity); recommendations for trials; and research recommendations. (C) 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：698 / 715

页数：18

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