Binding between outer membrane proteins of nontypeable Haemophilus influenzae and human nasopharyngeal mucin

被引：101

作者：

Reddy, MS

Bernstein, JM

Murphy, TF

Faden, HS

机构：

[1] SUNY BUFFALO,DEPT PEDIAT & OTOLARYNGOL,BUFFALO,NY 14214

[2] SUNY BUFFALO,SCH MED,DEPT MED,DIV INFECT DIS,BUFFALO,NY 14214

[3] SUNY BUFFALO,SCH MED,DEPT MICROBIOL,DIV INFECT DIS,BUFFALO,NY 14214

[4] SUNY BUFFALO,BUFFALO VET ADM HOSP,BUFFALO,NY 14214

[5] SUNY BUFFALO,CHILDRENS HOSP,DEPT PEDIAT,BUFFALO,NY 14214

来源：

INFECTION AND IMMUNITY | 1996年 / 64卷 / 04期

关键词：

D O I：

10.1128/IAI.64.4.1477-1479.1996

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacterial colonization of the epithelial cells precedes infection. Mucins of the epithelial cell secretions modulate bacterial colonization. This study was designed to understand the mechanism of mucin-bacterial interactions and in particular binding between nontypeable Haemophilus influenzae and nasopharyngeal mucin(s). In an overlay assay, binding appears to be mediated by outer membrane proteins P2 and P5 of bacteria and sialic acid-containing oligosaccharides of mucin.

引用

收藏

页码：1477 / 1479

页数：3

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