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Histone onco-modifications

被引：206
作者：
Fullgrabe, J. [1 ]
Kavanagh, E. [1 ]
Joseph, B. [1 ]
机构：
[1] Karolinska Inst, Canc Ctr Karolinska, Dept Oncol Pathol, S-17176 Stockholm, Sweden
来源：
ONCOGENE | 2011年 / 30卷 / 31期
基金：
瑞典研究理事会;
关键词：
histone modification; histone-modifying enzymes; carcinogenesis; acetylation; methylation; DNA-DAMAGE RESPONSE; H3; LYSINE; 9; MODIFICATIONS PREDICT PROGNOSIS; SQUAMOUS-CELL CARCINOMA; BREAST-CANCER CELLS; MODIFICATION PATTERNS; PROSTATE-CANCER; TRANSCRIPTIONAL REPRESSION; METHYLTRANSFERASE G9A; LUNG-CANCER;
D O I：
10.1038/onc.2011.121
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Post-translational modification of histones provides an important regulatory platform for processes such as gene expression, DNA replication and repair, chromosome condensation and segregation and apoptosis. Disruption of these processes has been linked to the multistep process of carcinogenesis. We review the aberrant covalent histone modifications observed in cancer, and discuss how these epigenetic changes, caused by alterations in histone-modifying enzymes, can contribute to the development of a variety of human cancers. As a conclusion, a new terminology 'histone onco-modifications' is proposed to describe post-translational modifications of histones, which have been linked to cancer. This new term would take into account the active contribution and importance of these histone modifications in the development and progression of cancer. Oncogene (2011) 30, 3391-3403; doi:10.1038/onc.2011.121; published online 25 April 2011
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收藏
页码：3391 / 3403
页数：13
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