The collagen-binding protein of Streptococcus mutans is involved in haemorrhagic stroke

被引：136

作者：

Nakano, Kazuhiko ^{[2
]}

Hokamura, Kazuya ^{[3
]}

Taniguchi, Naho ^{[2
]}

Wada, Koichiro ^{[1
]}

Kudo, Chiho ^{[4
]}

Nomura, Ryota ^{[2
]}

Kojima, Ayuchi ^{[2
]}

Naka, Shuhei ^{[2
]}

Muranaka, Yoshinori ^{[5
]}

Thura, Min ^{[3
]}

Nakajima, Atsushi ^{[6
]}

Masuda, Katsuhiko ^{[2
,7
]}

Nakagawa, Ichiro ^{[8
]}

Speziale, Pietro ^{[9
]}

Shimada, Nobumitsu ^{[10
]}

Amano, Atsuo ^{[11
]}

Kamisaki, Yoshinori ^{[1
]}

Tanaka, Tokutaro ^{[12
,13
]}

Umemura, Kazuo ^{[3
]}

Ooshima, Takashi ^{[2
]}

机构：

[1] Osaka Univ, Dept Pharmacol, Grad Sch Dent, Suita, Osaka 5650871, Japan

[2] Osaka Univ, Dept Pediat Dent, Grad Sch Dent, Suita, Osaka 5650871, Japan

[3] Hamamatsu Univ Sch Med, Dept Pharmacol, Hamamatsu, Shizuoka 4313192, Japan

[4] Osaka Univ, Dept Dent Anesthesiol, Grad Sch Dent, Suita, Osaka 5650871, Japan

[5] Hamamatsu Univ Sch Med, Lab Ultrastruct Res, Hamamatsu, Shizuoka 4313192, Japan

[6] Yokohama City Univ, Div Gastroenterol, Sch Med, Kanagawa 2360004, Japan

[7] Masuda Dent Clin, Osaka 5700015, Japan

[8] Tokyo Med & Dent Univ, Sect Bacterial Pathogenesis, Grad Sch Med & Dent Sci, Tokyo 1138510, Japan

[9] Univ Pavia, Dept Biochem, I-27100 Pavia, Italy

[10] Suita Municipal Hosp, Dept Neurosurg, Osaka 5640082, Japan

[11] Osaka Univ, Dept Prevent Dent, Grad Sch Dent, Suita, Osaka 5650871, Japan

[12] Seirei Hamamatsu Gen Hosp, Dept Neurosurg, Shizuoka 4308558, Japan

[13] Seirei Hamamatsu Gen Hosp, Stroke Care Ctr, Shizuoka 4308558, Japan

来源：

NATURE COMMUNICATIONS | 2011年 / 2卷

关键词：

INTRACEREBRAL HEMORRHAGE; INFECTIVE ENDOCARDITIS; ELECTROPHORETIC MOBILITY; PLASMINOGEN-ACTIVATOR; CEREBRAL-HEMORRHAGE; AGGREGATING AGENTS; BLOOD PLATELETS; RISK-FACTORS; MANAGEMENT; ADHESIN;

D O I：

10.1038/ncomms1491

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although several risk factors for stroke have been identified, one-third remain unexplained. Here we show that infection with Streptococcus mutans expressing collagen-binding protein (CBP) is a potential risk factor for haemorrhagic stroke. Infection with serotype k S. mutans, but not a standard strain, aggravates cerebral haemorrhage in mice. Serotype k S. mutans accumulates in the damaged, but not the contralateral hemisphere, indicating an interaction of bacteria with injured blood vessels. The most important factor for high-virulence is expression of CBP, which is a common property of most serotype k strains. The detection frequency of CBP-expressing S. mutans in haemorrhagic stroke patients is significantly higher than in control subjects. Strains isolated from haemorrhagic stroke patients aggravate haemorrhage in a mouse model, indicating that they are haemorrhagic stroke-associated. Administration of recombinant CBP causes aggravation of haemorrhage. Our data suggest that CBP of S. mutans is directly involved in haemorrhagic stroke.

引用

页数：10

共 34 条

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