Spectrin, α-actinin, and dystrophin

被引:105
作者
Broderick, MJF [1 ]
Winder, SJ
机构
[1] Univ Sheffield, Dept Biomed Sci, Sheffield S10 2TN, S Yorkshire, England
[2] Univ Glasgow, Inst Biomed & Life Sci, Dept Biochem & Mol Biol, Glasgow G12 8QQ, Lanark, Scotland
来源
FIBROUS PROTEINS: COILED-COILS, COLLAGEN AND ELASTOMERS | 2005年 / 70卷
关键词
D O I
10.1016/S0065-3233(04)70007-8
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Spectrin family proteins represent an important group of actin-bundling and membrane-anchoring proteins found in diverse structures from yeast to man. Arising from a common ancestral a-actinin gene through duplications and rearrangements, the family has increased to include the spectrins and dystrophin/utrophin. The spectrin family is characterized by the presence of spectrin repeats, actin binding domains, and EF hands. With increasing divergence, new domains and functions have been added such that spectrin and dystrophin also contain specialized protein-protein interaction motifs and regions for interaction with membranes and phospholipids. The acquisition of new domains also increased the functional complexity of the family such that the proteins perform a range of tasks way beyond the simple bundling of actin filaments by alpha-actinin in S. pombe. We discuss the evolutionary, structural, functional, and regulatory roles of the spectrin family of proteins and describe some of the disease traits associated with loss of spectrin family protein function.
引用
收藏
页码:203 / +
页数:46
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