Adverse effects of luteinizing hormone on fertility: fact or fantasy

被引：21

作者：

Homburg, R ^{[1
]}

机构：

[1] Hasharon Hosp, Rabin Med Ctr, Dept Obstet & Gynaecol, Fertil Unit, IL-49372 Petah Tiqwa, Israel

[2] Tel Aviv Univ, Sackler Sch Med, IL-69978 Tel Aviv, Israel

来源：

BAILLIERES CLINICAL OBSTETRICS AND GYNAECOLOGY | 1998年 / 12卷 / 04期

关键词：

polycystic ovary syndrome; luteinizing hormone concentrations; ovulation induction; miscarriage;

D O I：

10.1016/S0950-3552(98)80051-5

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

High tonic serum concentrations of luteinizing hormone (LH) in the follicular phase, frequently witnessed in polycystic ovary syndrome, have been associated with decreased reproductive function. Impaired rates of fertilization, conception and miscarriage are obtained when LH levels are high before oocytes are collected, during ovulation induction or in women with regular cycles. Conversely, treatment that decreases LH concentrations, such as gonadotrophin-releasing hormone analogue or laparoscopic ovarian puncture, eases induction of ovulation and pregnancy and improves miscarriage rates. Tonic hypersecretion of LH appears to induce premature oocyte maturation, causing the problems with fertilization and miscarriage.

引用

页码：555 / 563

页数：9

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