Monoclonal antibody-resistant mutants selected with a respiratory syncytial virus-neutralizing human antibody Fab fragment (Fab 19) define a unique epitope on the fusion (F) glycoprotein

被引：39

作者：

Crowe, JE

Firestone, CY

Crim, R

Beeler, JA

Coelingh, KL

Barbas, CF

Burton, DR

Chanock, RM

Murphy, BR

机构：

[1] NIAID, Resp Viruses Sect, Infect Dis Lab, NIH, Bethesda, MD 20892 USA

[2] Scripps Res Inst, La Jolla, CA 92037 USA

来源：

VIROLOGY | 1998年 / 252卷 / 02期

关键词：

D O I：

10.1006/viro.1998.9462

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A recombinant human antibody fragment, designated RSV Fab 19, efficiently neutralizes respiratory syncytial virus (RSV), Here we report the results of our sequence analysis of antibody escape mutants that identified F glycoprotein amino acids critical for binding of human or murine RSV F-neutralizing antibodies. (C) 1998 Academic Press.

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收藏

页码：373 / 375

页数：3

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