Synthesis and evaluation of potent and selective c-GMP phosphodiesterase inhibitors

被引：10

作者：

Ho, GD ^{[1
]}

Silverman, L ^{[1
]}

Bercovici, A ^{[1
]}

Puchalski, C ^{[1
]}

Tulshian, D ^{[1
]}

Xia, Y ^{[1
]}

Czarniecki, M ^{[1
]}

Green, M ^{[1
]}

Cleven, R ^{[1
]}

Zhang, HT ^{[1
]}

Fawzi, A ^{[1
]}

机构：

[1] Schering Plough Res Inst, Kenilworth, NJ 07033 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 01期

关键词：

D O I：

10.1016/S0960-894X(98)00681-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Syntheses and structure-activity relationships (SAR) of cGMP selective phosphodiesterase inhibitors are discussed. Potent and selective inhibitors are produced when the C-2 position of tetracyclic guanine 1 is substituted with alkyl chains containing six carbon atoms, (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7 / 12

页数：6

共 7 条

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