Minimally invasive treatment of renal cell carcinoma:: Comparison of 4 different monopolar radiofrequency devices

被引:21
作者
Häcker, A
Vallo, S
Weiss, C
Grobholz, R
Alken, P
Knoll, T
Michel, MS
机构
[1] Univ Heidelberg, Univ Hosp Mannheim, Dept Urol, Fac Clin Med Mannheim, D-68135 Mannheim, Germany
[2] Univ Heidelberg, Univ Hosp Mannheim, Dept Biomath, Fac Clin Med Mannheim, D-68135 Mannheim, Germany
[3] Univ Heidelberg, Univ Hosp Mannheim, Inst Pathol, Fac Clin Med Mannheim, D-68135 Mannheim, Germany
关键词
radiofrequency (RF) ablation; kidney; renal cell carcinoma; experimental study;
D O I
10.1016/j.eururo.2005.06.010
中图分类号
R5 [内科学]; R69 [泌尿科学(泌尿生殖系疾病)];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Objectives: Radiofrequency Ablation is an investigational treatment option for RCC. The aim of our study was to test the ablation algorithms of four different RF systems in a standardized ex vivo perfused porcine kidney model. Materials and methods: A multitine monopolar dry electrode (impedance-based system), a multitine monopolar dry electrode (temperature-based system), a single monopolar wet electrode (impedance-based system) and a single monopolar dry, internally-cooled electrode (impedance-based system) were selected. RF energy was applied at different treatment parameters (power with and without control, tissue temperature, saline enhancement) for 1, 3, 5 and 9 minutes in healthy perfused ex vivo porcine tissue. Each treatment parameter was repeated 5 times. Maximum vertical, long-axis and short-axis diameters of the macroscopic lesion were measured and lesion volumes/ shapes were calculated. Results: Lesion volumes increased significantly with the pre-selected tissue temperature and saline enhancement. Saline enhancement created larger, but irregular shaped lesions. The impedance-based system created lesion volumes that were predictable by treatment time and generator power. Lesions were unpredictable when uncontrolled generator power was applied. The created lesion shape was dependent on the selected electrode configuration. Conclusions: The currently available monopolar RFA systems offer different specific technical features to control tissue ablation. Detailed knowledge of the specific characteristics of each RF system is necessary to provide a higher chance of successful clinical outcome by complete and reliable ablation. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码:584 / 592
页数:9
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