Key strongylid nematodes of animals - Impact of next-generation transcriptomics on systems biology and biotechnology

被引:36
作者
Cantacessi, Cinzia [1 ]
Campbell, Bronwyn E. [1 ]
Gasser, Robin B. [1 ]
机构
[1] Univ Melbourne, Fac Vet Sci, Parkville, Vic 3010, Australia
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
Transcriptomics; Strongylid nematodes; Bioinformatics; Vaccine targets; Drug candidates; Ancylostoma-secreted proteins; Genomics; Next-generation sequencing; EXPRESSED SEQUENCE TAGS; TRANSMITTED HELMINTH INFECTIONS; HUMAN HOOKWORM INFECTIONS; OESOPHAGOSTOMUM DENTATUM INFECTIONS; TRICHOSTRONGYLUS-VITRINUS NEMATODA; HAEMONCHUS-CONTORTUS INFECTION; INTERNAL TRANSCRIBED SPACER; DOUBLE-STRANDED-RNA; FREE-LIVING STAGES; CAENORHABDITIS-ELEGANS;
D O I
10.1016/j.biotechadv.2011.08.016
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 [微生物学]; 090105 [作物生产系统与生态工程];
摘要
The advent and integration of high-throughput 'omic technologies (e.g., genomics, transcriptomics, proteomics and metabolomics) are becoming instrumental to assist fundamental explorations of the systems biology of organisms. In particular, these technologies now provide unique opportunities for global, molecular investigations of parasites. For example, studies of the transcriptomes (all transcripts in an organism, tissue or cell) of different species and/or developmental stages of parasitic nematodes provide insights into aspects of gene expression, regulation and function, which is a major step to understanding their biology. The purpose of this article was to review salient aspects of the systematics and biology of selected species of parasitic nematodes (particularly key species of the order Strongylida) of socio-economic importance, to describe conventional and advanced sequencing technologies and bioinformatic tools for large-scale investigations of the transcriptomes of these parasites and to highlight the prospects and implications of these explorations for developing novel methods of parasite intervention. (C) 2011 Elsevier Inc. All rights reserved.
引用
收藏
页码:469 / 488
页数:20
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