Utility of intravenous immune globulin in kidney transplantation: Efficacy, safety, and cost implications

被引：109

作者：

Jordan, S ^{[1
]}

Cunningham-Rundles, C

McEwan, R

机构：

[1] Cedars Sinai Med Ctr, Dept Pediat Nephrol & Transplant Immunol, Los Angeles, CA 90048 USA

[2] Mt Sinai Sch Med, New York, NY USA

[3] MEDBANK Maryland, Towson, MD USA

来源：

AMERICAN JOURNAL OF TRANSPLANTATION | 2003年 / 3卷 / 06期

关键词：

IVIG; kidney transplantation; panel reactive antibodies;

D O I：

10.1034/j.1600-6143.2003.00121.x

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Intravenous immunoglobulin preparations (IVIG) are known to be effective in the treatment of various autoimmune and inflammatory disorders into their immunomodulatory, immunoregulatory, and antiinflammatory properties. Recently, IVIG has been utilized in the management of highly sensitized patients awaiting renal transplantation. The mechanisms of suppression of panel reactive antibodies (PRA) in patients awaiting transplantation are currently under investigation and appear to be related to antiidiotypic antibodies present in IVIG preparations. In this review, the various immunomodulatory mechanisms attributable to IVIG and their efficacy in reducing PRAs will be described. In addition, the use of IVIG in solid organ transplant recipients will be reviewed. The adverse events, safety considerations, and economic impact of IVIG protocols for patients awaiting solid organ transplantation will be discussed.

引用

页码：653 / 664

页数：12

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