Bacterial and host factors implicated in nasal carriage of methicillin-resistant Staphylococcus aureus in mice

被引：47

作者：

González-Zorn, B

Senna, JPM

Fiette, L

Shorte, S

Testard, A

Chignard, M

Courvalin, P

Grillot-Courvalin, C

机构：

[1] Inst Pasteur, Unite Agents Antibacteriens, F-75724 Paris 15, France

[2] Inst Pasteur, Unite Rech & Expertise Histotechnol & Pathol, Paris, France

[3] Inst Pasteur, Unite Def Innee & Inflammat, INSERM, E336, Paris, France

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 03期

关键词：

D O I：

10.1128/IAI.73.3.1847-1851.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nasal carriage is a major risk factor for Staphylococcus aureus infection, especially for methicillin-resistant strains (MRSA). Using a mouse model of nasal carriage, we have compared several S. aureus strains and demonstrated increased colonization levels by MRSA in cystic fibrosis transmembrane conductance regulator-deficient mice and Toll-like receptor 2 (TLR2) -deficient mice but not TLR4-deficient mice.

引用

收藏

页码：1847 / 1851

页数：5

相关论文

共 27 条

[1] DISSEMINATION AMONG STAPHYLOCOCCI OF DNA-SEQUENCES ASSOCIATED WITH METHICILLIN RESISTANCE [J].

ARCHER, GL ;

NIEMEYER, DM ;

THANASSI, JA ;

PUCCI, MJ .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1994, 38 (03) :447-454

[2] The changing epidemiology of Staphylococcus aureus? [J].

Chambers, HF .

EMERGING INFECTIOUS DISEASES, 2001, 7 (02) :178-182

[3] Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance gene [J].

Chang, S ;

Sievert, DM ;

Hageman, JC ;

Boulton, ML ;

Tenover, FC ;

Downes, FP ;

Shah, S ;

Rudrik, JT ;

Pupp, GR ;

Brown, WJ ;

Cardo, D ;

Fridkin, SK .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 348 (14) :1342-1347

[4] Human β-defensins and toll-like receptors in the upper airway [J].

Claeys, S ;

de Belder, T ;

Holtappels, G ;

Gevaert, P ;

Verhasselt, B ;

van Cauwenberge, P ;

Bachert, C .

ALLERGY, 2003, 58 (08) :748-753

[5] Community-acquired methicillin-resistant Staphylococcus aureus infections in France:: Emergence of a single clone that produces Panton-Valentine leukocidin [J].

Dufour, P ;

Gillet, Y ;

Bes, M ;

Lina, G ;

Vandenesch, F ;

Floret, D ;

Etienne, J ;

Richet, H .

CLINICAL INFECTIOUS DISEASES, 2002, 35 (07) :819-824

[6] Staphylococcal resistance revisited:: community-acquired methicillin resistant Staphylococcus aureus -: an emerging problem for the management of skin and soft tissue infections [J].

Eady, EA ;

Cove, JH .

CURRENT OPINION IN INFECTIOUS DISEASES, 2003, 16 (02) :103-124

[7] Methicillin-resistant Staphylococcus aureus as a causative agent of postoperative intra-abdominal infection:: Relation to nasal colonization [J].

Fierobe, L ;

Decré, D ;

Mùller, C ;

Lucet, JC ;

Marmuse, JP ;

Mantz, J ;

Desmonts, JM .

CLINICAL INFECTIOUS DISEASES, 1999, 29 (05) :1231-1238

[8] Conversion of oxacillin-resistant staphylococci from heterotypic to homotypic resistance expression [J].

Finan, JE ;

Rosato, AE ;

Dickinson, TM ;

Ko, D ;

Archer, GL .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2002, 46 (01) :24-30

[9] Monitoring bioluminescent Staphylococcus aureus infections in living mice using a novel luxABCDE construct [J].

Francis, KP ;

Joh, D ;

Bellinger-Kawahara, C ;

Hawkinson, MJ ;

Purchio, TF ;

Contag, PR .

INFECTION AND IMMUNITY, 2000, 68 (06) :3594-3600

[10] Molecular epidemiology of community-acquired Staphylococcus aureus in families with and without cystic fibrosis patients [J].

Goerke, C ;

Kraning, K ;

Stern, M ;

Döring, G ;

Botzenhart, K ;

Wolz, C .

JOURNAL OF INFECTIOUS DISEASES, 2000, 181 (03) :984-989