Human cancer cell lines: fact and fantasy

被引:235
作者
Masters, JRW [1 ]
机构
[1] UCL, Inst Urol, London W1W 7EY, England
关键词
D O I
10.1038/35043102
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Cancer cell lines are used in many biomedical research laboratories. Why, then, are they often described as unrepresentative of the cells from which they were derived? Here, I argue that they have been unjustly accused. Under the right conditions, and with appropriate controls, property authenticated cancer cell lines retain the properties of the cancers of origin.
引用
收藏
页码:233 / 236
页数:4
相关论文
共 38 条
[1]   Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling [J].
Alizadeh, AA ;
Eisen, MB ;
Davis, RE ;
Ma, C ;
Lossos, IS ;
Rosenwald, A ;
Boldrick, JG ;
Sabet, H ;
Tran, T ;
Yu, X ;
Powell, JI ;
Yang, LM ;
Marti, GE ;
Moore, T ;
Hudson, J ;
Lu, LS ;
Lewis, DB ;
Tibshirani, R ;
Sherlock, G ;
Chan, WC ;
Greiner, TC ;
Weisenburger, DD ;
Armitage, JO ;
Warnke, R ;
Levy, R ;
Wilson, W ;
Grever, MR ;
Byrd, JC ;
Botstein, D ;
Brown, PO ;
Staudt, LM .
NATURE, 2000, 403 (6769) :503-511
[2]  
Dirks WG, 1999, IN VITRO CELL DEV-AN, V35, P558
[3]   p53 alterations in human leukemia-lymphoma cell lines:: in vitro artifact or prerequisite for cell immortalization? [J].
Drexler, HG ;
Fombonne, S ;
Matsuo, Y ;
Hu, ZB ;
Hamaguchi, H ;
Uphoff, CC .
LEUKEMIA, 2000, 14 (01) :198-206
[4]   Review of alterations of the cyclin-dependent kinase inhibitor INK4 family genes p15, p16, p18 and p19 in human leukemia-lymphoma cells [J].
Drexler, HG .
LEUKEMIA, 1998, 12 (06) :845-859
[5]  
DREXTER HG, 2000, ENCY CELL TECHNOLOGY
[6]   127 CULTURED HUMAN TUMOR-CELL LINES PRODUCING TUMORS IN NUDE MICE [J].
FOGH, J ;
FOGH, JM ;
ORFEO, T .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1977, 59 (01) :221-226
[7]  
Freshney R. I, 2010, CULTURE ANIMAL CELLS
[8]  
Gartler S M, 1967, Natl Cancer Inst Monogr, V26, P167
[9]  
GEY GO, 1952, CANCER RES, V12, P264
[10]  
GILBERT DA, 1990, AM J HUM GENET, V47, P499