Synthesis and pharmacological evaluation of pyrazoline derivatives as new anti-inflammatory and analgesic agents

被引：242

作者：

Amir, Mohammad ^{[1
]}

Kumar, Harish ^{[1
]}

Khan, Suroor A. ^{[1
]}

机构：

[1] Hamdard Univ, Fac Pharm, Dept Pharmaceut Chem, New Delhi 110062, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 03期

关键词：

pyrazoline; anti-inflammatory; analgesic; ulcerogenic; lipid peroxidation;

D O I：

10.1016/j.bmcl.2007.12.043

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

A series of 3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (2a-h) and 1-benzoyl-3-(4-biphenyl)-5-substituted phenyl-2-pyrazolines (3a-h) were synthesized by condensation of chalcones with hydrazine hydrate in solvent system ethanol and DMF. The newly synthesized compounds were screened for their anti-inflammatory and analgesic activity, and were compared with standard drug. Among the compounds studied, compound 2e showed more potent anti-inflammatory and analgesic activity than the standard drug along with minimum ulcerogenic index. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：918 / 922

页数：5

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