Diastereoselective synthesis, activity and chiral stability of cyclic alkoxyketone inhibitors of cathepsin K

被引：17

作者：

Fenwick, AE

Gribble, AD

Ife, RJ

Stevens, N

Witherington, J

机构：

[1] SmithKline Beecham Pharmaceut, Dept Med Chem, Harlow CM19 5AD, Essex, England

[2] SmithKline Beecham Pharmaceut, Dept Analyt Sci, Harlow CM19 5AD, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(00)00627-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The diastereoselective synthesis of a novel class of cathepsin K inhibitors together with their cathepsin K affinity and stability towards aqueous buffer is reported. (C) 2001 Published by Elsevier Science Ltd.

引用

页码：199 / 202

页数：4

共 8 条

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