Effect of Pore Architecture on Oxygen Diffusion in 3D Scaffolds for Tissue Engineering

被引：34

作者：

Ahn, Geunseon ^{[1
]}

Park, Jeong Hun ^{[1
]}

Kang, Taeyun ^{[1
]}

Lee, Jin Woo ^{[4
]}

Kang, Hyun-Wook ^{[3
]}

Cho, Dong-Woo ^{[1
,2
]}

机构：

[1] Pohang Univ Sci & Technol POSTECH, Dept Mech Engn, Pohang 790784, Kyeongbuk, South Korea

[2] Pohang Univ Sci & Technol POSTECH, Div Integrat Biosci & Biotechnol, Pohang 790784, Kyeongbuk, South Korea

[3] Wake Forest Univ, Wake Forest Inst Regenerat Med, Winston Salem, NC 27157 USA

[4] Univ Texas Austin, Dept Mech Engn, Austin, TX 78712 USA

来源：

JOURNAL OF BIOMECHANICAL ENGINEERING-TRANSACTIONS OF THE ASME | 2010年 / 132卷 / 10期

关键词：

three-dimensional scaffolds; pore architecture; oxygen diffusion; projection-based microstereolithography (pMSTL) system; sacrificial molding process; SOLID FREEFORM FABRICATION; CARTILAGINOUS CONSTRUCTS; GRADIENTS; POROSITY;

D O I：

10.1115/1.4002429

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 [生物物理学];

摘要：

The aim of this study was to maximize oxygen diffusion within a three-dimensional scaffold in order to improve cell viability and proliferation. To evaluate the effect of pore architecture on oxygen diffusion, we designed a regular channel shape with uniform diameter, referred to as cylinder shaped, and a new channel shape with a channel diameter gradient, referred to as cone shaped. A numerical analysis predicted higher oxygen concentration in the cone-shaped channels than in the cylinder-shaped channels, throughout the scaffold. To confirm these numerical results, we examined cell proliferation and viability in 2D constructs and 3D scaffolds. Cell culture experiments revealed that cell proliferation and viability were superior in the constructs and scaffolds with cone-shaped channels. [DOI: 10.1115/1.4002429]

引用

页码：1 / 5

页数：5

共 16 条

[1]

Development of a bi-pore scaffold using indirect solid freeform fabrication based on microstereolithography technology [J].