Immune mechanisms of HIV control

被引：32

作者：

Chakrabarti, Lisa A. ^{[1
]}

Simon, Viviana ^{[2
,3
]}

机构：

[1] Inst Pasteur, Unite Immunogenet Cellulaire, F-75724 Paris 15, France

[2] Mt Sinai Sch Med, Dept Med, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA

[3] Mt Sinai Sch Med, Dept Microbiol, Global Hlth & Emerging Pathogens Inst, New York, NY 10029 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2010年 / 22卷 / 04期

基金：

美国国家卫生研究院;

关键词：

CD4(+) T-CELLS; IMMUNODEFICIENCY-VIRUS CONTROLLERS; INTERFERON-PRODUCTION; VIRAL REPLICATION; ELITE CONTROLLERS; DENDRITIC CELLS; INFECTION; RESPONSES; ABSENCE; AVIDITY;

D O I：

10.1016/j.coi.2010.06.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV-1 can be contained by the immune system, as demonstrated by the existence of rare individuals who spontaneously control HIV-1 replication in the absence of antiretroviral therapy. Emerging evidence points to the importance of a very active cellular immune response in mediating HIV-1 control. The rapid induction of interferon-dependent HIV restriction factors, the presence of protective MHC class I alleles, and the development of a high avidity T-cell response may all cooperate in limiting HIV replication at an early stage. This review will focus on recent advances in understanding the immune mechanisms of HIV control, and on the lessons that may be drawn for the development of candidate HIV vaccines.

引用

页码：488 / 496

页数：9

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