A novel probe for imaging amyloid-β:: Synthesis of F-18 labelled BF-108, an Acridine Orange analog

被引：26

作者：

Shimadzu, H ^{[1
]}

Suemoto, T ^{[1
]}

Suzuki, M ^{[1
]}

Shiomitsu, T ^{[1
]}

Okamura, N ^{[1
]}

Kudo, YA ^{[1
]}

Sawada, T ^{[1
]}

机构：

[1] BF Res Inst, Natl Cardiovasc Ctr, Suita, Osaka 5650873, Japan

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2003年 / 46卷 / 08期

关键词：

F-18; 3-(2-fluoroethyl)ethylamino-6-diethylaminoacridine; BF-108; amyloid-beta; PET;

D O I：

10.1002/jlcr.716

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of 3-(2-[F-18]fluoroethyl)ethylamino-6-diethylaminoacridine ([F-18]BF-108), a potential positron-labelled probe for imaging amyloid-beta is described. The precursor tosylate derivative was fluorinated with [F-18]KF/Kryptofix 222 in acetonitrile, and the crude product was purified by semi-preparative HPLC to give the radiolabelled BF-108. The radiochemical purity was > 95% and the maximum specific activity was 33.9 TBq/mmol at the end of the synthesis (EOS). The synthesis time was 130 min from the end of bombardment (EOB). Copyright (C) 2003 John Wiley Sons, Ltd.

引用

页码：765 / 772

页数：8

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