Palladium-catalyzed asymmetric iodination of unactivated C-H bonds under mild conditions

被引：440

作者：

Giri, R ^{[1
]}

Chen, X ^{[1
]}

Yu, JQ ^{[1
]}

机构：

[1] Brandeis Univ, Dept Chem, Waltham, MA 02454 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 14期

关键词：

asymmetric catalysis; C-H activation; chiral auxiliaries; iodine; palladium;

D O I：

10.1002/anie.200462884

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Specific, asymmetric, and mild: Oxazoline (Oxa), a removable chelating chiral auxiliary, assists in the asymmetric activation of C(sp3)-H bonds at the β position and C(sp 2)-H bonds at the γ position. Pd-(OAc)2 is an effective catalyst for the selective and asymmetric iodination of methyl, cyclopropyl, and aryl groups at room temperature (see formulae). © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2112 / 2115

页数：4

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