Domino reactions for library synthesis of small molecules in combinatorial chemistry

被引：159

作者：

Tietze, LF ^{[1
]}

Lieb, ME ^{[1
]}

机构：

[1] Univ Gottingen, Inst Organ Chem, D-37077 Gottingen, Germany

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 1998年 / 2卷 / 03期

关键词：

D O I：

10.1016/S1367-5931(98)80010-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Domino reactions are highly efficient processes that allow the synthesis of complex molecules starting from simple substrates, in a straightforward fashion. The transformations are extremely useful for the design of small-molecule libraries by combinatorial chemistry if multicomponent domino reactions are employed. The reactions can be performed in solution, as well as on solid support, and give access to highly diverse molecules; in addition, their use in automated synthesis is possible.

引用

页码：363 / 371

页数：9

共 44 条

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