Recognizing death: the phagocytosis of apoptotic cells

被引：289

作者：

Platt, N ^{[1
]}

da Silva, RP ^{[1
]}

Gordon, S ^{[1
]}

机构：

[1] Univ Oxford, Sir William Dunn Sch Pathol, Oxford OX1 3RE, England

来源：

TRENDS IN CELL BIOLOGY | 1998年 / 8卷 / 09期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0962-8924(98)01329-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Although apoptotic cell death is widespread, dying cells are rarely seen in situ because of their rapid clearance by neighbouring phagocytes. Phagocytic recognition of apoptotic cells is less well understood than the death programme itself; but an increasing number of recent studies are highlighting its importance. This review discusses the nature of the receptors that have been implicated in apoptotic cell phagocytosis, the mechanisms of uptake and the immunological consequences of apoptotic cell ingestion.

引用

页码：365 / 372

页数：8

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