Molecular systems biology in drug development

被引：13

作者：

Silver, P. A. ^{[1
]}

Way, J. C.

机构：

[1] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

[2] EMD Serono Lexigen Res Ctr, Billerica, MA USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2007年 / 82卷 / 05期

关键词：

D O I：

10.1038/sj.clpt.6100293

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Molecular systems biology seeks to explain the behavior of complex cellular systems through a multicomponent analysis. We illustrate this approach and its relevance to drug development by reviewing two examples of the interplay between cellular processes and drugs: the internalization and recycling of oncogenic receptors, their ligands and therapeutic antibodies; and strategies for discovering drugs that affect intracellular protein kinase pathways.

引用

页码：586 / 590

页数：5

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