Preparation of magnetite-dextran microspheres by ultrasonication

被引:25
作者
Xia, ZF
Wang, GB
Tao, KX
Li, JX
机构
[1] Huazhong Univ Sci & Technol, Xiehe Hosp, Tongji Med Coll, Laparoscopy Ctr, Wuhan 430022, Hubei, Peoples R China
[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Biomed Engn, Wuhan 430030, Peoples R China
关键词
magnetite-dextran microsphere; ultrasonication; atomic force microscopy; particle size; dextran; scanning electron microscopy;
D O I
10.1016/j.jmmm.2005.01.059
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
An improved method of preparing magnetite-dextran microspheres by ultrasonication is proposed. Several parameters were evaluated and the characteristics of the microspheres investigated by scanning electron microscope (SEM), atomic force microscope (AFM), particle size analyzer and magnetometer. The results show that the initial Fe/ dextran ratio is the most effective parameter for both the size and the magnetic properties. (c) 2005 Published by Elsevier B.V.
引用
收藏
页码:182 / 186
页数:5
相关论文
共 17 条
  • [1] Magnetic chitosan microspheres:: preparation and characterization
    Denkbas, EB
    Kiliçay, E
    Birlikseven, C
    Öztürk, E
    [J]. REACTIVE & FUNCTIONAL POLYMERS, 2002, 50 (03) : 225 - 232
  • [2] OVERVIEW OF CONTRAST ENHANCEMENT WITH IRON-OXIDES
    FRIJA, G
    CLEMENT, O
    DEKERVILER, E
    [J]. INVESTIGATIVE RADIOLOGY, 1994, 29 : S75 - S77
  • [3] Single-dose toxicity study of hepatic intra-arterial infusion of doxorubicin coupled to a novel magnetically targeted drug carrier
    Goodwin, SC
    Bittner, CA
    Peterson, CL
    Wong, G
    [J]. TOXICOLOGICAL SCIENCES, 2001, 60 (01) : 177 - 183
  • [4] Iinuma H, 2000, INT J CANCER, V89, P337, DOI 10.1002/1097-0215(20000720)89:4<337::AID-IJC4>3.0.CO
  • [5] 2-R
  • [6] Effects of magnetic fluid hyperthermia (MFH) on C3H mammary carcinoma in vivo
    Jordan, A
    Scholz, R
    Wust, P
    Fahling, H
    Krause, J
    Wlodarczyk, W
    Sander, B
    Vogl, T
    Felix, R
    [J]. INTERNATIONAL JOURNAL OF HYPERTHERMIA, 1997, 13 (06) : 587 - 605
  • [7] Li MQ, 1996, CHEM J CHINESE U, V17, P147
  • [8] Lubbe AS, 1996, CANCER RES, V56, P4686
  • [9] Molday R.S., 1984, US Patent, Patent No. [4452773, 4, 452, 773]
  • [10] Biodegradable nanoparticles for drug and gene delivery to cells and tissue
    Panyam, J
    Labhasetwar, V
    [J]. ADVANCED DRUG DELIVERY REVIEWS, 2003, 55 (03) : 329 - 347