The relevance of tick bites to the production of IgE antibodies to the mammalian oligosaccharide galactose-α-1,3-galactose

被引:468
作者
Commins, Scott P. [1 ]
James, Hayley R. [1 ]
Kelly, Libby A. [1 ]
Pochan, Shawna L. [1 ]
Workman, Lisa J. [1 ]
Perzanowski, Matthew S. [2 ]
Kocan, Katherine M. [3 ]
Fahy, John V. [4 ]
Nganga, Lucy W. [5 ]
Ronmark, Eva [6 ]
Cooper, Philip J. [7 ,8 ]
Platts-Mills, Thomas A. E. [1 ]
机构
[1] Univ Virginia Hlth Syst, Asthma & Allerg Dis Ctr, Charlottesville, VA 22908 USA
[2] Columbia Univ, Mailman Sch Publ Hlth, New York, NY USA
[3] Oklahoma State Univ, Ctr Vet Hlth Sci, Stillwater, OK 74078 USA
[4] Univ Calif San Francisco, Dept Med, San Francisco, CA USA
[5] Kenya Med Res Inst KEMRI, Ctr Resp Dis, Nairobi, Kenya
[6] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden
[7] Univ San Francisco Quito, Cumbaya, Quito, Ecuador
[8] Univ Liverpool Liverpool Sch Trop Med, Liverpool, Merseyside, England
基金
英国惠康基金; 美国国家卫生研究院;
关键词
Ticks; anaphylaxis; oligosaccharide; alpha-gal; IgE antibody to CCD; AMBLYOMMA-AMERICANUM ACARI; ACUTE ASTHMA; ANAPHYLAXIS; CETUXIMAB; ALLERGENS; RISK; SENSITIZATION; INFECTIONS; IXODIDAE; IMMUNITY;
D O I
10.1016/j.jaci.2011.02.019
中图分类号
R392 [医学免疫学];
学科分类号
100108 [医学免疫学];
摘要
Background: In 2009, we reported a novel form of delayed anaphylaxis to red meat that is related to serum IgE antibodies to the oligosaccharide galactose-alpha-1,3-galactose (alpha-gal). Most of these patients had tolerated meat for many years previously. The implication is that some exposure in adult life had stimulated the production of these IgE antibodies. Objectives: We sought to investigate possible causes of this IgE antibody response, focusing on evidence related to tick bites, which are common in the region where these reactions occur. Methods: Serum assays were carried out with biotinylated proteins and extracts bound to a streptavidin ImmunoCAP. Results: Prospective studies on IgE antibodies in 3 subjects after tick bites showed an increase in levels of IgE to alpha-gal of 20fold or greater. Other evidence included (1) a strong correlation between histories of tick bites and levels of IgE to alpha-gal (chi(2) = 26.8, P < .001), (2) evidence that these IgE antibodies are common in areas where the tick Amblyomma americanum is common, and (3) a significant correlation between IgE antibodies to alpha-gal and IgE antibodies to proteins derived from A americanum (r(s) = 0.75, P < .001). Conclusion: The results presented here provide evidence that tick bites are a cause, possibly the only cause, of IgE specific for alpha-gal in this area of the United States. Both the number of subjects becoming sensitized and the titer of IgE antibodies to alpha-gal are striking. Here we report the first example of a response to an ectoparasite giving rise to an important form of food allergy. (J Allergy Clin Immunol 2011;127:1286-93.)
引用
收藏
页码:1286 / U310
页数:14
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