Polymeric micelles to deliver photosensitizers for photodynamic therapy

被引：274

作者：

van Nostrum, CF ^{[1
]}

机构：

[1] Utrecht Inst Pharmaceut Sci, Dept Pharmaceut, NL-3508 TB Utrecht, Netherlands

来源：

ADVANCED DRUG DELIVERY REVIEWS | 2004年 / 56卷 / 01期

关键词：

polymeric micelles; photodynamic therapy; pH-responsive; pluronics; polyion complex micelles; poly(N-isopropylacrylamide); biodistribution;

D O I：

10.1016/j.addr.2003.07.013

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Polymeric micelles are emerging as attractive drug delivery systems. Hydrophobic drugs including photosensitizers for photodynamic therapy can be covalently bound or physically entrapped in the core of the micelles and thus be systemically delivered to, for example, tumors using passive or active targeting strategies. Polymers used for photosensitizer encapsulation include pluronics, poly(ethylene glycol) (PEG)-lipid conjugates, and pH-sensitive poly(N-isopropylacrylamide) based micelles or polyion complex (PIC) micelles. This paper reviews the results obtained so far, including drug loading, biodistribution studies, and therapeutic efficiency. The pH-sensitive micelles appear to be promising candidates for photosensitizer delivery. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：9 / 16

页数：8

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