Living dangerously:: How Helicobacter pylori survives in the human stomach

被引：423

作者：

Montecucco, C

Rappuoli, R

机构：

[1] Univ Padua, Ctr CNR Biomembrane, I-35121 Padua, Italy

[2] Univ Padua, Dipartimento Sci Biomed, I-35121 Padua, Italy

[3] Chiron SpA, Ctr Ric IRIS, I-53100 Siena, Italy

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2001年 / 2卷 / 06期

关键词：

D O I：

10.1038/35073084

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Helicobacter pylori was already present in the stomach of primitive humans as they left Africa and spread through the world. Today, it still chronically infects more than 50% of the human population, causing, in some cases, severe diseases such as peptic ulcers and stomach cancer. To succeed in these long-term associations, H. pylori has developed a unique set of virulence factors, which allow survival in a unique and hostile ecological niche - the human stomach.

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页码：457 / 466

页数：10

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