Therapeutic opportunities in the B7/CD28 family of ligands and receptors

被引：32

作者：

Carreno, BM ^{[1
]}

Carter, LL ^{[1
]}

Collins, M ^{[1
]}

机构：

[1] Wyeth Res, Inflammat, Cambridge, MA 02140 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2005年 / 5卷 / 04期

关键词：

D O I：

10.1016/j.coph.2005.02.003

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The CD28 and B7 protein families are critical regulators of immune responses and, in the past few years, several new family members have been identified. Preclinical studies exploring the role of members of the CD28 and B7 families support the targeting of these pathways for new therapeutic approaches. Indeed, recent Phase I clinical studies using agonists and antagonists of the CD28/CTLA-4/B7 pathway have shown promise in inflammatory diseases and cancer.

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收藏

页码：424 / 430

页数：7

相关论文

共 74 条

[1] CTLA4Ig-mediated blockade of T-cell costimulation in patients with psoriasis vulgaris [J].

Abrams, JR ;

Lebwohl, MG ;

Guzzo, CA ;

Jegasothy, BV ;

Goldfarb, MT ;

Goffe, BS ;

Menter, A ;

Lowe, NJ ;

Krueger, G ;

Brown, MJ ;

Weiner, RS ;

Birkhofer, MJ ;

Warner, GL ;

Berry, KK ;

Linsley, PS ;

Krueger, JG ;

Ochs, HD ;

Kelley, SL ;

Kang, SW .

JOURNAL OF CLINICAL INVESTIGATION, 1999, 103 (09) :1243-1252

[2] Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes [J].

Agata, Y ;

Kawasaki, A ;

Nishimura, H ;

Ishida, Y ;

Tsubata, T ;

Yagita, H ;

Honjo, T .

INTERNATIONAL IMMUNOLOGY, 1996, 8 (05) :765-772

[3] The programmed death-1 (PD-1) pathway regulates autoimmune diabetes in nonobese diabetic (NOD) mice [J].

Ansari, MJI ;

Salama, AD ;

Chitnis, T ;

Smith, RN ;

Yagita, H ;

Akiba, H ;

Yamazaki, T ;

Azuma, M ;

Iwai, H ;

Khoury, SJ ;

Auchincloss, H ;

Sayegh, MH .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (01) :63-69

[4] Phase I trial of a B7-1 (CD80) gene modified autologous tumor cell vaccine in combination with systemic interleukin-2 in patients with metastatic renal cell carcinoma [J].

Antonia, SJ ;

Seigne, J ;

Diaz, J ;

Muro-Cacho, C ;

Extermann, M ;

Farmelo, MJ ;

Friberg, M ;

Alsarraj, M ;

Mahany, JJ ;

Pow-Sang, J ;

Cantor, A ;

Janssen, W .

JOURNAL OF UROLOGY, 2002, 167 (05) :1995-2000

[5] Treatment with humanized monoclonal antibodies against CD80 and CD86 combined with sirolimus prolongs renal allograft survival in cynomolgus monkeys [J].

Bîrsan, T ;

Hausen, B ;

Higgins, JP ;

Hubble, RW ;

Klupp, J ;

Stalder, M ;

Celniker, A ;

Friedrich, S ;

O'Hara, RM ;

Morris, RE .

TRANSPLANTATION, 2003, 75 (12) :2106-2113

[6] Blockade of programmed death-1 engagement accelerates graft-versus-host disease lethality by an IFN-γ-dependent mechanism [J].

Blazar, BR ;

Carreno, BM ;

Panoskaltsis-Mortari, A ;

Carter, L ;

Iwai, Y ;

Yagita, H ;

Nishimura, H ;

Taylor, PA .

JOURNAL OF IMMUNOLOGY, 2003, 171 (03) :1272-1277

[7] Regulation of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA-synthetase by CTLA-4-Fc in human CD4+ T cells [J].

Boasso, A ;

Herbeuval, JP ;

Hardy, AW ;

Winkler, C ;

Shearer, GM .

BLOOD, 2005, 105 (04) :1574-1581

[8] Blockade of programmed death-1 Ligands on dendritic cells enhances T cell activation and cytokine production [J].

Brown, JA ;

Dorfman, DM ;

Ma, FR ;

Sullivan, EL ;

Munoz, O ;

Wood, CR ;

Greenfield, EA ;

Freeman, GJ .

JOURNAL OF IMMUNOLOGY, 2003, 170 (03) :1257-1266

[9] The B7 family of ligands and its receptors: New pathways for costimulation and inhibition of immune responses [J].

Carreno, BM ;

Collins, M .

ANNUAL REVIEW OF IMMUNOLOGY, 2002, 20 :29-53

[10] Identification of 41g-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis [J].

Castriconi, R ;

Dondero, A ;

Augugliaro, R ;

Cantoni, C ;

Carnemolla, B ;

Sementa, AR ;

Negri, F ;

Conte, R ;

Corrias, MV ;

Moretta, L ;

Moretta, A ;

Bottino, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (34) :12640-12645

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