Enantiomerically pure 1,2,5-triphenylphospholane through the synthesis and resolution of the chiral trans-(2,5)-diphenylphospholanic acid

被引：77

作者：

Guillen, F ^{[1
]}

Fiaud, JC ^{[1
]}

机构：

[1] Univ Paris 11, Inst Chim Mol Orsay, Inst React Organ Select, F-91405 Orsay, France

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 15期

关键词：

phospholanes; phosphinic acid and derivatives; enantioselection; asymmetric hydrogenation;

D O I：

10.1016/S0040-4039(99)00329-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and resolution of trans-(2,5)-diphenylphospholanic acid 7 is described. The phosphinic acid 7 was converted into optically active (1,2,5)-triphenylphospholane 5 which was used as a chiral ligand in Rh-catalyzed hydrogenation of N-acetyl dehydrophenylalanine methyl ester to give quantitative yield of methyl N-acetylwphenylalaninate with 82 % e.e. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2939 / 2942

页数：4

共 17 条

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