A concise regioselective synthesis of hydroxyazaisoindolinones and their conversion into pyridopyridazinones

被引：22

作者：

Brzezinski, JZ

Bzowski, HB

Epsztajn, J

机构：

[1] Department of Organic Chemistry, University of Łodz, 90-136 Łódź

来源：

TETRAHEDRON | 1996年 / 52卷 / 09期

关键词：

D O I：

10.1016/0040-4020(95)01109-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of pyridopyridazinones 7 and 8 via the reaction of hydroxyazaisoindolinones 5 and 6 with hydrazine hydrate is described. Compounds 7 and 8 were then subjected to reactions with alkyl halides to furnish N-alkyl derivatives. Only in the reaction of pyridopyridazinone 8 with benzyl bromide was the O-benzylpyridopyridazine 14b formed in addition to the N-benzylpyridopyridazinone 14a.

引用

页码：3261 / 3272

页数：12

共 98 条

[1] ABDELFATTAH B, 1987, EGYPT J PHARM SCI, V28, P383
[2] ABDELFATTAH B, 1988, EGYPT J PHARM SCI, V29, P259
[3] AKASHI H, 1986, Patent No. 6145817
[4] SOME FURTHER STUDIES ON TUBERCULOSTATIC COMPOUNDS
BAVIN, EM
DRAIN, DJ
SEILER, M
SEYMOUR, DE
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1952, 4 (11) : 844 - 855
[5] BEDIAR H, 1987, J PRAKT CHEM, V329, P675
[6] Bottari F., 1956, GAZZ CHIM ITAL, V86, P990
[7] BRISTOL JA, 1986, CARDIOVASCULAR DRUGS, P279
[8] BRUMAGNIEZ N, 1990, Patent No. 2647676
[9] BUDAVARI S, 1989, MERCK INDEX, P1208
[10] BUDAVARI S, 1989, MERCK INDEX, P222

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