Aggregation-induced emission nanoparticles as photosensitizer for two-photon photodynamic therapy

被引：90

作者：

Alifu, Nuernisha ^{[1
]}

Dong, Xiaobiao ^{[2
]}

Li, Dongyu ^{[1
]}

Sun, Xianhe ^{[1
]}

Zebibula, Abudureheman ^{[3
]}

Zhang, Deqing ^{[2
]}

Zhang, Guanxin ^{[2
]}

Qian, Jun ^{[1
]}

机构：

[1] Zhejiang Univ, State Key Lab Modern Opt Instrumentat, Ctr Opt & Electromagnet Res, JORCEP Sino Swedish Joint Res Ctr Photon, Hangzhou 310058, Zhejiang, Peoples R China

[2] Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Lab Organ Solids, Beijing 100190, Peoples R China

[3] Zhejiang Univ, Sir Run Run Shaw Hosp Coll Med, Dept Urol, Hangzhou 310016, Zhejiang, Peoples R China

来源：

MATERIALS CHEMISTRY FRONTIERS | 2017年 / 1卷 / 09期

基金：

中国国家自然科学基金;

关键词：

CANCER-THERAPY; ORGANIC NANOPARTICLES; SILICA NANOPARTICLES; QUANTUM DOTS; GOLD NANOROD; IN-VITRO; AIE; ABSORPTION; FLUORESCENCE; CELLS;

D O I：

10.1039/c7qm00092h

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Two-photon excited fluorescence microscopy and nanoparticle-assisted photodynamic therapy (PDT) are two important areas in biomedical research, and their combination can be more beneficial. A type of red emissive photosensitizer (PS) with aggregation-induced emission (AIE) features, which is called tetraphenylethylene (TPE-red), was synthesized and further encapsulated with poly(styrene-co-maleic anhydride) (PSMA) to form nanoparticles. Two-photon fluorescence, as well as two-photon excited reactive oxygen species (ROS) generation by TPE-red-PSMA nanoparticles, was characterized. A large two-photon absorption cross-section was observed at 1040 nm with a femtosecond (fs) laser. PDT via two-photon excitation was well realized on tumor cells, using TPE-red-PSMA nanoparticles as PSs under 1040 nm fs laser excitation. Based on our study, we believe that two-photon excited PDT with AIE-active PSs has great potential applications in deep tissue imaging-guided therapy.

引用

页码：1746 / 1753

页数：8

共 41 条

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