Abnormalities in cell cycle control in cancer and their clinical implications

被引：27

作者：

Sgambato, A

Flamini, G

Cittadini, A

Weinstein, IB

机构：

[1] Univ Cattolica Sacro Cuore, Ctr Ric Oncol Giovanni XXIII, I-00168 Rome, Italy

[2] Columbia Univ Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, New York, NY 10032 USA

来源：

TUMORI | 1998年 / 84卷 / 04期

关键词：

cell cycle; growth control; tumorigenesis;

D O I：

10.1177/030089169808400401

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recent studies indicate that the functions of several genes that control the cell cycle are altered during the carcinogenic process and that these changes perturb both cell proliferation and genomic stability, thus promoting cell transformation and enhancing the process of tumor progression. The purpose of this paper is to review current information on the role of cyclins and related genes in the control of the mammalian cell cycle, the types of abnormalities in these genes found in human tumors and the possible clinical implications of these findings.

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收藏

页码：421 / 433

页数：13

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