Solid phase synthesis of phosphinic acid endothelin converting enzyme inhibitors

被引：29

作者：

Lloyd, J

Schmidt, JB

Hunt, JT

Barrish, JC

Little, DK

Tymiak, AA

机构：

[1] Bristol-Myers Squibb P., Princeton, NJ 08543-4000

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 12期

关键词：

D O I：

10.1016/0960-894X(96)00227-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have synthesized a series of phosphinic acids by solid phase peptide synthesis where we have explored effect on inhibition of changes in the P-2' binding site. The most potent compounds show inhibition of ECE similar to phosphoramidon. Copyright (C) 1996 Elsevier Science Ltd

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收藏

页码：1323 / 1326

页数：4

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