Anti-Saccharomyces cerevisiae (ASCA) and anti-endomysial antibodies in spondyloarthritis

被引：10

作者：

Andretta, Marianne A. ^{[1
]}

Vieira, Thais D. ^{[1
]}

Nishiara, Renato ^{[2
]}

Skare, Thelma L. ^{[1
]}

机构：

[1] Evangel Univ Hosp, Rheumatol Unit, BR-80310420 Curitiba, PR, Brazil

[2] Clin Hosp, Immunopathol Lab, Curitiba, PR, Brazil

来源：

RHEUMATOLOGY INTERNATIONAL | 2012年 / 32卷 / 02期

关键词：

Anti-Saccharomyces cerevisiae antibody; Anti-endomysial antibody; Spondyloarthritis; Ankylosing spondylitis; CELIAC-DISEASE; ANKYLOSING-SPONDYLITIS; MECHANISMS;

D O I：

10.1007/s00296-010-1722-9

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Spondyloarthritis (SpA) are diseases with increased gut inflammation. To search for (anti-Saccharomyces cerevisiae) ASCA IgA, ASCA IgG, and anti-endomysial antibodies (EmA-IgA) in a cohort of 70 patients with SpA, we found 18.6% (13/70) positive for IgA-ASCA in the SpA group and 3/57 (5.2%) in the control group (P = 0.031). ASCA IgG and EmA-IgA were found at the same frequency in SpA and controls. No relationship of ASCA IgA positivity could be established with disease activity (measured by ESR, C-reactive protein, and BASDAI), presence of uveitis, or peripheral arthritis neither with functional status measured by BASFI. SpA patients present an increase in the IgA-ASCA positivity without any relationship to disease activity, functional index, clinical profile or the presence of HLA-B27. There is no evidence of higher prevalence of EmA-IgA in SpA patients in the studied sample.

引用

页码：551 / 554

页数：4

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