A non-synonymous variant in SLC30A8 is not associated with type 1 diabetes in the Danish population

被引：17

作者：

Brorsson, Caroline ^{[1
]}

Bergholdt, Regine ^{[1
]}

Sjogren, Marketa ^{[2
]}

Eising, Stefanie ^{[1
]}

Sorensen, Karina Meden ^{[3
]}

Hougaard, David M. ^{[3
]}

Orho-Melander, Marju ^{[2
]}

Groop, Leif ^{[2
]}

Pociot, Flemming ^{[1
,2
]}

机构：

[1] Steno Diabet Ctr, DK-2820 Gentofte, Denmark

[2] Lund Univ, Malmo Univ Hosp, Diabet & Endocrinol Res Unit, Dept Clin Sci, Malmo, Sweden

[3] Statens Serum Inst, Dept Clin Biochem, DK-2300 Copenhagen, Denmark

来源：

MOLECULAR GENETICS AND METABOLISM | 2008年 / 94卷 / 03期

关键词：

SLC30A8; zinc transporter; type; 1; diabetes; genetics; beta-cell function;

D O I：

10.1016/j.ymgme.2008.02.011

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Genome-wide association scans in type 2 diabetes (T2D) have identified a risk variant, rs13266634 (Arg325Trp), in SLC30A8 on chromosome 8. SLC30A8 encodes a beta-cell specific zinc-ion transporter and rs13266634 has been shown to affect insulin secretion. Recently, autoantibodies for Slc30A8 with high predictive value were demonstrated in individuals with type 1 diabetes (T1 D), making this gene an interesting T1 D candidate gene. We genotyped rs13266634 in 3008 cases and controls and 246 families from Denmark. Association to T1 D could not be demonstrated. (c) 2008 Elsevier Inc. All rights reserved.

引用

页码：386 / 388

页数：3

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