Sex steroids and cognitive function

被引:121
作者
Luine, V. N. [1 ]
机构
[1] CUNY Hunter Coll, Dept Psychol, New York, NY 10065 USA
关键词
cognition; oestradiol; memory; hippocampus; learning;
D O I
10.1111/j.1365-2826.2008.01710.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Gonadal hormones, most notably oestradiol, enhance some aspects of cognitive function in animal and human models. However, the demonstrated effects are often not large and inconsistent across studies. Nonetheless, because increased numbers of women are living longer in a state of oestrogen deprivation, research on this topic continues to be important. This review traces major developments concerning hormonal influences on cognition and provides some insights from recent studies that may be fruitful for future research.
引用
收藏
页码:866 / 872
页数:7
相关论文
共 86 条
[1]   Length of postovariectomy interval and age, but not estrogen replacement, regulate N-methyl-D-aspartate receptor mRNA levels in the hippocampus of female rats [J].
Adams, MM ;
Oung, T ;
Morrison, JH ;
Gore, AC .
EXPERIMENTAL NEUROLOGY, 2001, 170 (02) :345-356
[2]   Sex differences in behavioral and neurochemical profiles after chronic stress: Role of housing conditions [J].
Beck, KD ;
Luine, VN .
PHYSIOLOGY & BEHAVIOR, 2002, 75 (05) :661-673
[3]   Food deprivation modulates chronic stress effects on object recognition in male rats: role of monoamines and amino acids [J].
Beck, KD ;
Luine, VN .
BRAIN RESEARCH, 1999, 830 (01) :56-71
[4]   Spatial learning and memory at defined points of the estrous cycle: Effects on performance of a hippocampal-dependent task [J].
Berry, B ;
McMahan, R ;
Gallagher, M .
BEHAVIORAL NEUROSCIENCE, 1997, 111 (02) :267-274
[5]   Increased daily handling of ovariectomized rats enhances performance on a radial-maze task and obscures effects of estradiol replacement [J].
Bohacek, Johannes ;
Daniel, Jill M. .
HORMONES AND BEHAVIOR, 2007, 52 (02) :237-243
[6]   Chronic restraint stress enhances radial arm maze performance in female rats [J].
Bowman, RE ;
Zrull, MC ;
Luine, VN .
BRAIN RESEARCH, 2001, 904 (02) :279-289
[7]   Multiple pathways transmit neuroprotective effects of gonadal steroids [J].
Bryant, Damani N. ;
Sheldahl, Laird C. ;
Marriott, Lisa K. ;
Shapiro, Robert A. ;
Dorsa, Daniel M. .
ENDOCRINE, 2006, 29 (02) :199-207
[8]   Estradiol replacement enhances working memory in middle-aged rats when initiated immediately after ovariectomy but not after a long-term period of ovarian hormone deprivation [J].
Daniel, JM ;
Hulst, JL ;
Berbling, JL .
ENDOCRINOLOGY, 2006, 147 (01) :607-614
[9]   Estrogen enhances performance of female rats during acquisition of a radial arm maze [J].
Daniel, JM ;
Fader, AJ ;
Spencer, AL ;
Dohanich, GP .
HORMONES AND BEHAVIOR, 1997, 32 (03) :217-225
[10]   Castration in rats impairs performance during acquisition of a working memory task and exacerbates deficits in working memory produced by scopolamine and mecamylamine [J].
Daniel, JM ;
Winsauer, PJ ;
Moerschbaecher, JM .
PSYCHOPHARMACOLOGY, 2003, 170 (03) :294-300