This paper explores whether new structural economics, and more broadly Structuralist approaches, could add to our understanding of transition in Central and Eastern Europe - and ultimately asks whether new structural economics and transition economics might be extended or integrated into a dynamic model of structural transformation that could better account for this particular development experience and provide policy guidance for the future. We have presented three perspectives - new structural economics, transition economics and the Neo-Schumpetarian approach - all of them emphasising different aspects of structural transformation. Their relative explanatory power depends on the context - for example, the extent of distortions in the economy, the quality of the institutions and where a country finds itself relative to the world technology frontier - and the questions we are interested in understanding. We suggest that, to date, the Neo-Schumpetarian approach offers the most promising and persuasive story line to think about this difficult challenge.