Effect of spinal infusion of L-NAME, a nitric oxide synthase inhibitor, on spinal tolerance and dependence induced by chronic intrathecal morphine in the rat

被引：29

作者：

Dunbar, S

Yaksh, TL

机构：

[1] Department of Anesthesiology 0818, University of California, San Diego, San Diego, CA 92093

来源：

NEUROSCIENCE LETTERS | 1996年 / 207卷 / 01期

关键词：

rat; nitric oxide synthase inhibition; L-N-G-nitroarginine methyl ester; spinal; morphine; tolerance; dependence; withdrawal; naloxone;

D O I：

10.1016/0304-3940(96)12481-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Systemic L-N-G-nitroarginine methyl ester or L-NAME (LN), a nitric oxide synthase inhibitor, has been reported to attenuate systemic opioid tolerance and withdrawal. Intrathecal co-administration of LN (100 and 500 nmol/mu 1 per h) with spinal morphine produced only a small diminishing attenuation of tolerance and attenuated only one of seven signs of withdrawal. These results show that LN has little effect on morphine tolerance and withdrawal at spinal sites.

引用

页码：33 / 36

页数：4

共 22 条

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[2] THE NMDA RECEPTOR ANTAGONIST-MK-801 PREVENTS LONG-LASTING NONASSOCIATIVE MORPHINE-TOLERANCE IN THE RAT [J].