A novel monoclonal antibody 107-1A4 with high prostate specificity: generation, characterization of antigen expression, and targeting of human prostate cancer xenografts

被引：19

作者：

Brown, LG ^{[1
]}

Wegner, SK ^{[1
]}

Wang, H ^{[1
]}

Buhler, KR ^{[1
]}

Arfman, EW ^{[1
]}

Lange, PH ^{[1
]}

Vessella, RL ^{[1
]}

机构：

[1] Univ Washington, Dept Urol, Seattle, WA 98195 USA

来源：

PROSTATE CANCER AND PROSTATIC DISEASES | 1998年 / 1卷 / 04期

关键词：

monoclonal antibodies; prostate; prostate cancer; xenograft;

D O I：

10.1038/sj.pcan.4500233

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Monoclonal antibodies with high specificity for prostate tissue are of interest for prostate cancer research and treatment. Reactivity and specificity of a new murine monoclonal antibody, 107-1A4, was assessed by immunohistochemistry, ELISA and indirect immunofluorescence (IDIF). 107-1A4 stained all normal and malignant prostate tissue specimens while reactivity to non-prostate tissue was limited to the tubules of the normal kidney and renal cell carcinoma. Twenty two human cell lines were included in the reactivity survey; only the immunogen prostate cancer line LNCaP reacted with 107-1A4. Seminal plasma proteins PSA, PAP, PSMA, and PSP-94 were determined not to be the 107-1A4 antigen.

引用

页码：208 / 215

页数：8

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