Linoleic acid intake and susceptibility of very-low-density and low-density lipoproteins to oxidation in men

被引:49
作者
Louheranta, AM [1 ]
PorkkalaSarataho, EK [1 ]
Nyyssonen, MK [1 ]
Salonen, RM [1 ]
Salonen, JT [1 ]
机构
[1] UNIV KUOPIO,PUBL HLTH RES INST,SF-70211 KUOPIO,FINLAND
关键词
linoleic acid; oxidation susceptibility; atherogenic lipoproteins; men;
D O I
10.1093/ajcn/63.5.698
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Lipoprotein peroxidation is thought to play an important role in atherogenesis. In the Kuopio Atherosclerosis Prevention Study (KAPS) the intake of fat and fatty acids, the oxidation susceptibility of the plasma very-low-density + low-density lipoprotein (VLDL+LDL) fraction (by induction with copper or hemin and hydrogen peroxide), and concentrations of plasma antioxidants, serum lipids, and lipoproteins were measured in 393 men. In the multivariate-regression model dietary linoleic acid was the most important determinant of the maximal oxidation velocity for the hemin assay (standardized regression coefficient = 0.294, P < 0.0001). In the copper assay the association of dietary linoleic acid and maximal oxidation velocity was second in order of strength (standardized regression coefficient = 0.324, P < 0.0001). We conclude that high linoleic acid intake is associated with increased oxidation susceptibility of atherogenic lipoproteins in men.
引用
收藏
页码:698 / 703
页数:6
相关论文
共 45 条
[1]   OXIDATION OF LOW-DENSITY LIPOPROTEINS - INTRAINDIVIDUAL VARIABILITY AND THE EFFECT OF DIETARY LINOLEATE SUPPLEMENTATION [J].
ABBEY, M ;
BELLING, GB ;
NOAKES, M ;
HIRATA, F ;
NESTEL, PJ .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1993, 57 (03) :391-398
[2]   HEMIN - A POSSIBLE PHYSIOLOGICAL MEDIATOR OF LOW-DENSITY-LIPOPROTEIN OXIDATION AND ENDOTHELIAL INJURY [J].
BALLA, G ;
JACOB, HS ;
EATON, JW ;
BELCHER, JD ;
VERCELLOTTI, GM .
ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (06) :1700-1711
[3]   EFFECTS OF DIETS RICH IN MONOUNSATURATED FATTY-ACIDS ON PLASMA-LIPOPROTEINS - THE JERUSALEM NUTRITION STUDY - HIGH MUFAS VS HIGH PUFAS [J].
BERRY, EM ;
EISENBERG, S ;
HARATZ, D ;
FRIEDLANDER, Y ;
NORMAN, Y ;
KAUFMANN, NA ;
STEIN, Y .
AMERICAN JOURNAL OF CLINICAL NUTRITION, 1991, 53 (04) :899-907
[4]   EFFECT OF DIETARY MONOUNSATURATED AND POLYUNSATURATED FATTY-ACIDS ON THE SUSCEPTIBILITY OF PLASMA LOW-DENSITY LIPOPROTEINS TO OXIDATIVE MODIFICATION [J].
BONANOME, A ;
PAGNAN, A ;
BIFFANTI, S ;
OPPORTUNO, A ;
SORGATO, F ;
DORELLA, M ;
MAIORINO, M ;
URSINI, F .
ARTERIOSCLEROSIS AND THROMBOSIS, 1992, 12 (04) :529-533
[5]   LIPOPROTEIN METABOLISM IN THE MACROPHAGE - IMPLICATIONS FOR CHOLESTEROL DEPOSITION IN ATHEROSCLEROSIS [J].
BROWN, MS ;
GOLDSTEIN, JL .
ANNUAL REVIEW OF BIOCHEMISTRY, 1983, 52 :223-261
[6]  
Committee on Diet and Health Food and Nutrition Board Commission on Life Sciences National Research Council (U.S.), 1989, DIET HLTH IMPL RED C
[7]   ENHANCED SUSCEPTIBILITY TO INVITRO OXIDATION OF THE DENSE LOW-DENSITY-LIPOPROTEIN SUBFRACTION IN HEALTHY-SUBJECTS [J].
DEGRAAF, J ;
HAKLEMMERS, HLM ;
HECTORS, MPC ;
DEMACKER, PNM ;
HENDRIKS, JCM ;
STALENHOEF, AFH .
ARTERIOSCLEROSIS AND THROMBOSIS, 1991, 11 (02) :298-306
[8]  
DOLECEK TA, 1991, WORLD REV NUTR DIET, V66, P205
[9]   CONTINUOUS MONITORING OF INVITRO OXIDATION OF HUMAN LOW-DENSITY LIPOPROTEIN [J].
ESTERBAUER, H ;
STRIEGL, G ;
PUHL, H ;
ROTHENEDER, M .
FREE RADICAL RESEARCH COMMUNICATIONS, 1989, 6 (01) :67-75
[10]  
HEGSTED DM, 1965, AM J CLIN NUTR, V17, P281