Asymmetric pinacol coupling of aromatic aldehydes with TiCl2/enantiopure amine or hydrazine reagents

被引：45

作者：

Enders, D ^{[1
]}

Ullrich, EC ^{[1
]}

机构：

[1] Rhein Westfal TH Aachen, Inst Organ Chem, D-52074 Aachen, Germany

来源：

TETRAHEDRON-ASYMMETRY | 2000年 / 11卷 / 19期

关键词：

D O I：

10.1016/S0957-4166(00)00379-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Asymmetric pinacol coupling of aromatic aldehydes under homogeneous conditions with TiCl2 in the presence of enantiopure amines or hydrazines afforded 1,2-diols in moderate to excellent yields with good dl-diastereoselectivities and enantioselectivities in the range of 6-65% ee. A non-linear temperature effect ('principle of isoinversion') has been examined. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：3861 / 3865

页数：5

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