Immune Responses to HIV Vaccines and Potential Impact on Control of Acute HIV-1 Infection

被引：13

作者：

McElrath, M. Juliana ^{[1
]}

机构：

[1] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, Seattle, WA 98109 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2010年 / 202卷

基金：

美国国家卫生研究院;

关键词：

T-CELL RESPONSES; ESCAPE; COMBINATION; EVOLUTION; STEP;

D O I：

10.1086/655658

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Unanticipated results from 2 recent candidate human immunodeficiency virus type 1 (HIV-1) vaccine regimens in large-scale international trials highlight the importance of understanding the optimal earliest immune defense against HIV-1 infection. Presented here are key findings in these vaccine studies with relevance to the development of future vaccines to control acute HIV-1 infection.

引用

页码：S323 / S326

页数：4

共 19 条

[1] Selective escape from CD8+ T-cell responses represents a major driving force of human immunodeficiency virus type 1 (HIV-1) sequence diversity and reveals constraints on HIV-1 evolution [J].

Allen, TM ;

Altfeld, M ;

Geer, SC ;

Kalife, ET ;

Moore, C ;

O'Sullivan, KM ;

DeSouza, I ;

Feeney, ME ;

Eldridge, RL ;

Maier, EL ;

Kaufmann, DE ;

Lahaie, MP ;

Reyor, L ;

Tanzi, G ;

Johnston, MN ;

Brander, C ;

Draenert, R ;

Rockstroh, JK ;

Jessen, H ;

Rosenberg, ES ;

Mallal, SA ;

Walker, BD .

JOURNAL OF VIROLOGY, 2005, 79 (21) :13239-13249

[2] Evolution of innate and adaptive effector cell functions during acute HIV-1 infection [J].

Alter, Galit ;

Teigen, Nickolas ;

Ahern, Ryan ;

Streeck, Hendrik ;

Meier, Angela ;

Rosenberg, Eric S. ;

Altfeld, Marcus .

JOURNAL OF INFECTIOUS DISEASES, 2007, 195 (10) :1452-1460

[3] Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial [J].

Buchbinder, Susan P. ;

Mehrotra, Devon V. ;

Duerr, Ann ;

Fitzgerald, Daniel W. ;

Mogg, Robin ;

Li, David ;

Gilbert, Peter B. ;

Lama, Javier R. ;

Marmor, Michael ;

del Rio, Carlos ;

McElrath, M. Juliana ;

Casimiro, Danilo R. ;

Gottesdiener, Keith M. ;

Chodakewitz, Jeffrey A. ;

Corey, Lawrence ;

Robertson, Michael N. .

LANCET, 2008, 372 (9653) :1881-1893

[4] Comprehensive analysis of human immunodeficiency virus type 1 (HIV71)-specific gamma interferon-secreting CD8+ T cells in primary HIV-1 infection [J].

Cao, JH ;

McNevin, J ;

Holte, S ;

Fink, L ;

Corey, L ;

McElrath, AJ .

JOURNAL OF VIROLOGY, 2003, 77 (12) :6867-6878

[5] Evolution of CD8+ T cell immunity and viral escape following acute HIV-1 infection [J].

Cao, JH ;

McNevin, J ;

Malhotra, U ;

McElrath, MJ .

JOURNAL OF IMMUNOLOGY, 2003, 171 (07) :3837-3846

[6] Initial events in establishing vaginal entry and infection by human immunodeficiency virus type-1 [J].

Hladik, Florian ;

Sakchalathorn, Polachai ;

Ballweber, Lamar ;

Lentz, Gretchen ;

Fialkow, Michael ;

Eschenbach, David ;

McElrath, M. Juliana .

IMMUNITY, 2007, 26 (02) :257-270

[7] Optimization and validation of an 8-color intracellular cytokine staining (ICS) assay to quantify antigen-specific T cells induced by vaccination [J].

Horton, Helen ;

Thomas, Evan P. ;

Stucky, Jason A. ;

Frank, Ian ;

Moodie, Zoe ;

Huang, Yunda ;

Chiu, Ya-Lin ;

McElrath, M. Juliana ;

De Rosa, Stephen C. .

JOURNAL OF IMMUNOLOGICAL METHODS, 2007, 323 (01) :39-54

[8] Preservation of T cell proliferation restricted by protective HLA alleles is critical for immune control of HIV-1 infection [J].

Horton, Helen ;

Frank, Ian ;

Baydo, Ruth ;

Jalbert, Emilie ;

Penn, Justin ;

Wilson, Sean ;

McNevin, John P. ;

McSweyn, Matthew D. ;

Lee, Deborah ;

Huang, Yunda ;

De Rosa, Stephen C. ;

McElrath, M. Juliana .

JOURNAL OF IMMUNOLOGY, 2006, 177 (10) :7406-7415

[9] Antibody-dependent cell-mediated cytotoxic responses in participants enrolled in a phase I/II ALVAC-HIV/AIDSVAX® B/E prime-boost HIV-1 vaccine trial in Thailand [J].

Karnasuta, C ;

Paris, RM ;

Cox, JH ;

Nitayaphan, S ;

Pitisuttithum, P ;

Thongcharoen, P ;

Brown, AE ;

Gurunathan, S ;

Tartaglia, J ;

Heyward, WL ;

McNeil, JG ;

Birx, DL ;

de Souza, MS .

VACCINE, 2005, 23 (19) :2522-2529

[10] CD8+ T-cell responses to different HIV proteins have discordant associations with viral load [J].

Kiepiela, Photini ;

Ngumbela, Kholiswa ;

Thobakgale, Christina ;

Ramduth, Dhanwanthie ;

Honeyborne, Isobella ;

Moodley, Eshia ;

Reddy, Shabashini ;

de Pierres, Chantal ;

Mncube, Zenele ;

Mkhwanazi, Nompumelelo ;

Bishop, Karen ;

van der Stok, Mary ;

Nair, Kriebashnie ;

Khan, Nasreen ;

Crawford, Hayley ;

Payne, Rebecca ;

Leslie, Alasdair ;

Prado, Julia ;

Prendergast, Andrew ;

Frater, John ;

McCarthy, Noel ;

Brander, Christian ;

Learn, Gerald H. ;

Nickle, David ;

Rousseau, Christine ;

Coovadia, Hoosen ;

Mullins, James I. ;

Heckerman, David ;

Walker, Bruce D. ;

Goulder, Philip .

NATURE MEDICINE, 2007, 13 (01) :46-53

← 1 2 →