The other side of the nearly neutral theory, evidence of slightly advantageous back-mutations

被引:68
作者
Charlesworth, Jane [1 ]
Eyre-Walker, Adam [1 ]
机构
[1] Univ Sussex, Sch Life Sci, Ctr Study Evolut, Brighton BN1 9QG, E Sussex, England
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1073/pnas.0705456104
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We argue that if there is a category of slightly deleterious mutations, then there should be a category of slightly advantageous back-mutations. We show that when there are both slightly deleterious and advantageous back-mutations, there is likely to be an increase in the rate of evolution after a population size expansion. This increase in the rate of evolution is short-lived. However, we show how its signature can be captured by comparing the rate of evolution in species that have undergone population size expansion versus contraction. We test our model by comparing the pattern of evolution in pairs of island and mainland species in which the colonization event was either island-to-mainland (population size expansion) or mainland-to-island (contraction). We show that the predicted pattern of evolution is observed.
引用
收藏
页码:16992 / 16997
页数:6
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