The INK4a/ARF tumor suppressor: one gene - two products - two pathways

被引：233

作者：

Chin, L

Pomerantz, J

DePinho, RA

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Adult Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Dermatol, Boston, MA 02115 USA

[3] Albert Einstein Coll Med, Dept Microbiol & Immunol, New York, NY 10461 USA

[4] Harvard Univ, Sch Med, Dept Med, Boston, MA 02115 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 08期

关键词：

D O I：

10.1016/S0968-0004(98)01236-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Functional inactivation of the retinoblastoma (RB) and p53 pathways appears to be a rite of passage for all cancerous cells and results in disruption of cell-cycle regulation and deactivation of the apoptotic response that normally ensues. The INK4a/ARF locus sits at the nexus of these two growth-control pathways, by virtue of its ability to generate two distinct products: the p16(INK4a) protein, a cyclin-dependent kinase inhibitor that functions upstream of RE; and the p19(ARF) protein, which blocks MDM2 inhibition of p53 activity. This 'one gene - two products - two pathways' arrangement provides a basis for the prominence of INK4a/ARF in tumorigenesis.

引用

页码：291 / 296

页数：6

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